CHOLER, noun

1. The bile. By the superabundance of this fluid, anger was formerly supposed to be produced; or perhaps the opinion was that the bile caused the inflamed appearance of the face in anger. Hence,

2. Anger; wrath; irritation of the passions.

Cholera Morbus, a sudden evacuation of bile, both upwards and downwards.

First occurrence in the Bible(KJV): Daniel 8:7