Probably from G5443 through the idea of isolation; to {watch} that {is} be on guard (literally or figuratively); by implication to preserve. {obey}avoid: - {beware} keep ({self}) {observe} save. Compare G5083.
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Matrix
Act 5:23Saying, The prison truly found we shut with all safety, and the keepersG5441 standing without before the doors: but when we had opened, we found no man within.
Act 12:6And when Herod would have brought him forth, the same night Peter was sleeping between two soldiers, bound with two chains: and the keepersG5441 before the door kept the prison.
Act 12:19And when Herod had sought for him, and found him not, he examined the keepersG5441, and commanded that they should be put to death. And he went down from Judaea to Caesarea, and there abode.